Advantix is a monthly preventative for dogs that both repels and kills fleas, ticks, and mosquitoes. Advantix combines imidacloprid and permethrin to repel and kill fleas, ticks, and mosquitoes. Each ingredient begins to affect pests on contact, attacking parasite nerve cells at different sites. When combined, the two compounds overwhelm the parasite's nervous system. This leads to rapid paralysis and death of the parasite. It repels and kills ticks before they can attach and bite. Advantix stops biting fleas within three to five minutes and kills 98-100 percent within 12 hours.